É«É«À²

The Single-Molecule Dynamics in Cells group takes an interdisciplinary approach to solve fundamental questions about how living systems adapt to extreme environments, employing a range of techniques from biophysics, molecular biology, genetics, to computational biology. 

We use super-resolution microscopy and single molecule tracking to record the movement of individual molecules inside individual live cells. Single molecule dynamics report on the molecular interactions in real-time, acting as a probe for the intracellular environment. The research will also contribute to the development of robust synthetic biology applications and novel assay solutions.

If this speaks to you, please send an email with your CV and research interests.

Research Highlights

• R. Jagadeesan, S. Dash, C.S.D. Palma, I.S.C. Baptista, V. Chauhan, ´³.&²Ô²ú²õ±è;²Ñä°ì±ð±ôä, A.S. Ribeiro (2025) . Science Advances, 11(20):eadl3570, doi:10.1126/sciadv.adl3570
• E.A. Abbondanzieri, A.B. Badrinarayanan, D. Barillà, S.D. Bell, F. Blombach, J.Y. Bouet, S. Bulgheresi, Q.A.D. Cao, R.T. Dame, C. Dekker, M. Demuysere, O. Espéli, P.C.M. Fogg, P.L. Freddolino, M. Ganji, T.M. Gerson, D.C. Grainger, L.W. Hamoen, J. Harju, A. Hocher, C.M. Hustmyer, J.K. Kaljevic, M.K. Karney, N. Kleckner, G. Laloux, R. Landick, V.S. Lioy, W.L. Liu, C.L. Liu, J. Mäkelä, A.S. Meyer, A. Noy, M.P. Pineau, K. Premrajka, L.R. Racki, F-Z.M. Rashid, K. Schnetz, S. Schwab, M. TiÅ¡ma, A.I. van der Sijs, T. van Heesch, R. van Raaphorst, J. Vreede, A.W. Walker, J-C. Walter, S.C. Weber, P.A. Wiggins, H.J. Wing, J. Xiao, Z. Zhang (2025) . Molecular Microbiology, 123(2):89-100, doi:10.1111/mmi.15347
• J. Mäkelä*, A. Papagiannakis*, W.H. Lin, M.C. Lanz, S. Glenn, M. Swaffer, G.K. Marinov, J.M. Skotheim, C. Jacobs-Wagner (2024) . eLife, 13:RP97465, doi:10.7554/eLife.97465.3
• ​​​​J.P. Prince, J.R. Bolla, G.L.M. Fisher, J. Mäkelä, C.V. Robinson, L.K.  Arciszewska, D.J. Sherratt (2021) . Nature Communications 12, 6721
• G.L.M. Fisher, J.R. Bolla, K.V. Rajasekar, J. Mäkelä, R. Baker, M. Zhou, J. Prince, M. Stracy, C.V. Robinson, L.K. Arciszewska, D.J. Sherratt (2021) . eLife, 10:e70444
• J. Mäkelä*, S. Uphoff, D.J. Sherratt* (2021)  PNAS, 118(33): e2022078118
• J. Mäkelä and D.J. Sherratt (2020). Current Genetics, 66:895–899
• J. Mäkelä and D.J. Sherratt (2020) . Molecular Cell, 78(2):250-260
• K.V. Rajasekar, R. Baker, G.L.M. Fisher, J.R. Bolla, J. Mäkelä, M. Tang, K. Zawadzka, O. Koczy, F. Wagner, C.V. Robinson, L.K. Arciszewska, D.J. Sherratt (2019) . Nucleic Acids Research, 47(18):9696-9707
• A. Hofmann*, J. Mäkelä*, D.J. Sherratt, D. Heermann, S.M. Murray (2019) . eLife, 8:e46564          
• N. Banaz*, J. Mäkelä*, S. Uphoff (2019) . Journal of Physics D: Applied Physics, 52:064002